WO2007103535A3 - Cellular predictive models for toxicities - Google Patents
Cellular predictive models for toxicities Download PDFInfo
- Publication number
- WO2007103535A3 WO2007103535A3 PCT/US2007/005985 US2007005985W WO2007103535A3 WO 2007103535 A3 WO2007103535 A3 WO 2007103535A3 US 2007005985 W US2007005985 W US 2007005985W WO 2007103535 A3 WO2007103535 A3 WO 2007103535A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- toxicities
- predictive models
- models
- stimuli
- subset
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
Abstract
Methods for generating models for predicting biological activity of a stimulus test population of cells are provided. The models may be used to classify or predict the effect of stimuli on cells. In certain embodiments, the methods involve receiving data comprising values for dependent variables associated with stimuli; preparing a set of cell populations based on the data received; identifying a subset of the cell populations to be used in generating a model from data associated with the subset, wherein the model is provided to predict activity of a test population.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78148406P | 2006-03-09 | 2006-03-09 | |
US60/781,484 | 2006-03-09 | ||
US78238006P | 2006-03-14 | 2006-03-14 | |
US60/782,380 | 2006-03-14 | ||
GB0605351A GB2435922A (en) | 2006-03-09 | 2006-03-17 | Cellular predictive models for cholestasis |
GB0605351.6 | 2006-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007103535A2 WO2007103535A2 (en) | 2007-09-13 |
WO2007103535A3 true WO2007103535A3 (en) | 2008-09-04 |
Family
ID=38475582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/005985 WO2007103535A2 (en) | 2006-03-09 | 2007-03-07 | Cellular predictive models for toxicities |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007103535A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007136724A2 (en) | 2006-05-17 | 2007-11-29 | Cellumen, Inc. | Method for automated tissue analysis |
CA3212002A1 (en) | 2011-03-17 | 2012-09-20 | Cernostics, Inc. | Systems and compositions for diagnosing barrett's esophagus and methods of using the same |
JP7003109B2 (en) * | 2016-04-11 | 2022-02-21 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | High-throughput method for accurate prediction of compound-induced liver injury |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040086873A1 (en) * | 2002-10-31 | 2004-05-06 | Johnson Peter C. | System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets |
US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
US6873914B2 (en) * | 2001-11-21 | 2005-03-29 | Icoria, Inc. | Methods and systems for analyzing complex biological systems |
-
2007
- 2007-03-07 WO PCT/US2007/005985 patent/WO2007103535A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6873914B2 (en) * | 2001-11-21 | 2005-03-29 | Icoria, Inc. | Methods and systems for analyzing complex biological systems |
US20040086873A1 (en) * | 2002-10-31 | 2004-05-06 | Johnson Peter C. | System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets |
US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
Non-Patent Citations (4)
Title |
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BROXUP ET AL.: "Morphometric Evaluation of Hepatocellular Proliferative Lesions in the Rat Liver", TOXICOLOGIC PATHOLOGY, vol. 16, no. 4, 1988 * |
DE LONGUEVILLE ET AL.: "Use of Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatoxicants on Primary Cultures on Rat Hepatocoytes", TOXICOLOGICAL SCIENCES, vol. 75, 2003, pages 378 - 392 * |
ERLER B.S. ET AL.: "A Study of Hepatocellular Carcinoma Using Morphometric and Densitometric Image Analysis", AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol. 100, 1993, pages 151 - 157 * |
ERLER B.S. ET AL.: "Methods in Laboratory Investigation: Image Analysis and Diagnostic Classification of Hepatocellular Carcinoma Using Neural Networks and Multivariate Discriminant Functions", LABORATORY INVESTIGATION, vol. 71, no. 3, 1994, pages 446 - 451 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007103535A2 (en) | 2007-09-13 |
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